Clinical and Epidemiological Characteristics of Patients with Diagnosis of Hemolytic-Uremic Syndrome Hospitalized at the Instituto Nacional de Salud del Niño between 2002 and 2009
DOI:
https://doi.org/10.61651/rped.2012v65n3p122-130Keywords:
Hemolytic Uremic Syndrome, Acute Renal FailureAbstract
Objective: Determine clinical and epidemiological characteristics of patients with Hemolytic-Uremic Syndrome (SHU).
Methods: A descriptive, retrospective, longitudinal study. Were included patients with diagnosis of SHU, hospitalized in the INSN from January 1, 2002 until December 31, 2009. Population: 174 patients.
Results: The hospitalary incidence rate (TIH) was 2.01 per 1000 hospitalized children. 57% were male patients. The most frequently age group at presentation was 13 to 18 months, 77% of the patients were younger than 25 months of age, with a median age of 18 months. The 85% of the patients came from Lima and Callao. Seasonal incidence with bimodal trend spring- summer was observed in 67% of the cases. The median time of diarrhea duration was 7 days (range 4). The 97% of the patients presented diarrheal prodrome with a median duration of 7 days, 77% of these had bloody diarrhea; 90% of the all patients received previous antibiotic treatment. In the 85% of the patients SHU develops during the diarrheal prodrome. 76% of the all patients presented SHU classic triad. 72% had arterial hypertension, 28% seizures and 65% severe anemia. 61% of patients presented oliguric acute renal failure (ARF). 46% required dialysis. The patients were hospitalized for a median of 13 days (range 10). The lethality was 2.3%.
Conclusions: The TIH has increased significantly (4 times more than the five year period 1982- 1986). The most frequent age was under 25 months, with median age of 18 months. Increase of patients proceeding from other regions of the country (15%). Seasonal incidence with bimodal trend spring-summer. Predominance of the typical variety of the HUS (D+). The SHU develops during the diarrheal prodrome. Predominance of the SHU classic triad. Increase of the nonoliguric ARF (39%). The lethality was similar to another Latin- American literature.
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