Sepsis in preterm newborns on mothers with premature rupture of membranes who received antenatal corticosteroids
Estudio Ganador del Primer Puesto en el XXVII Congreso Peruano de Pediatría
DOI:
https://doi.org/10.61651/rped.2013v66n1p17-22Keywords:
Neonatal Sepsis, Fetal Membranes, Premature Rupture, Adrenal Cortex HormonesAbstract
Introduction: The utility of antenatal corticosteroids has been shown in several studies, mainly in reducing mortality and neonatal respiratory distress syndrome (RDS) in infants of mothers with intact membranes. The effect on mothers with preterm premature rupture of membranes (PRM) is controversial, due to the discrepancies on the increase of early neonatal sepsis in different studies.
Objective: To determine whether the use of antenatal corticosteroids in the context of PRM increases the risk of neonatal sepsis.
Materials and methods: A retrospective cohort of pregnancies with PRM between 24 and 34 weeks were studied. Participants were divided into three groups according to their exposure to antenatal steroids. The primary outcome was the presence of neonatal sepsis. Student's t was used to compare means and chi-square statistic to assess the association between qualitative variables.
Results: 130 records of preterms with a history of PRM were analyzed. Only 93 were included to the study, of which 9% developed early neonatal sepsis and 13% late neonatal sepsis. No significant difference were found in the incidence of early neonatal sepsis (p = 0.59), nor congenital pneumonia (p = 0.93) or neonatal death (p = 0.56) with antenatal corticosteroid use in PRM.
Conclusions: Antenatal corticosteroids in RPM is safe. An increase in the incidence of neonatal sepsis and death in preterms were not found.
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