Treatment of cystic fibrosis pulmonary disease with hypertonic saline solution
DOI:
https://doi.org/10.61651/rped.2009v62n1p25-28Keywords:
Cystic Fibrosis, Saline Solution, HypertonicAbstract
Cystic fibrosis is a multisystemic disease that predominantly affects the airways. The main cause of morbidity and mortality is the respiratory compromise. The depletion of the airway surface liquid is felt to be one of the main pathophysiologic events. The pulmonary disease is caused by the inability of the airways to keep their surface hydrated with airway plugging, infection and progressive obstructive lung disease. The mechanism of action of hypertonic saline is felt to be the restoration of the airway surface liquid with the introduction of an osmotic gradient on the surface of the airways. This review focuses on the use of hypertonic saline because it gives us the opportunity to discuss a fundamental pathophysiologic aspect of the disease and understand the relative importance of one of the less expensive therapies for the pulmonary disease in cystic fibrosis.
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