Case Report: Systemic Manifestations of Mixed Connective Tissue Disease in teenage female
DOI:
https://doi.org/10.61651/rped.2020v72n1p34-39Keywords:
Mixed Connective Tissue Disease, AntibodiesAbstract
Mixed Connective Tissue Disease (MCTD) is extremely rare in the child population; diagnosis is based on the presence of clinical features of lupus, sclerosis and poly-dermatomyositis associated to the presence of high titers of Anti U1 snRNP1,2. We describe the case of a 14-year-old girl without previous history, who entered the INSNSB due to persistent fever, severe malnutrition, prostration and pericardial effusion; whose skin biopsy showed signs of sclerosis and also had high levels of Anti-RNP, demonstrating this disease. After starting treatment, she presented resolution of the effusion, and was discharged.Clinical manifestations in MCTD are very variable, initially it is nonspecific, however, it should be suspected in children with multisystemic disease without apparent cause, since the diagnosis and early treatment reduce the morbidity and mortality of this disease. Keywords: Mixed Connective Tissue Disease, AntiRNP, systemic manifestations.
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