NEONATAL HYPERTHYROIDISM
DOI:
https://doi.org/10.61651/rped.2025v77n2p27-29Keywords:
Neonatal hyperthyroidism , Hypoglycemia , Thyrotoxicosis , Transient hyperthyroidism , Anti-TSH receptor antibodies , Neonatal managementAbstract
We present the case of a newborn male diagnosed with transient neonatal hyperthyroidism, a rare condition in clinical practice. The main clinical manifestation during the adaptation period was persistent hypoglycemia, accompanied by signs of hypercatabolism. The patient's mother had a history of hyperthyroidism diagnosed in 2019 with irregular treatment with antithyroid drugs. The newborn was diagnosed at 8 days of age, considering maternal history and clinical signs such as low birth weight, small for gestational age, tremors, poor suckling, persistent hypoglycemia, and poor weight gain. Thyroid profiles confirmed the suspicion: TSH 0.121 uUI/ml, free T4 41.58 pmol/l, TSI 104%. Treatment was initiated with thiamazole and propranolol, with favorable clinical outcome after therapy. This case represents an unusual presentation of transient neonatal hyperthyroidism, given that its main manifestation was hypoglycemia, a rare finding in this entity.
Downloads
References
De Groot et al. (2019). Management of neonatal hyperthyroidism. J Pediatr Endocrinol Metab. 32(4): 441-448.
Ross et al. (2020). Congenital and Neonatal Thyrotoxicosis. Endocrinol Metab Clin North Am. 49(2): 437-453.
Vanderpump et al. (2017). The management of Graves’ disease in pregnancy. Clin Endocrinol (Oxf). 86(1): 2-9.
Silva et al. (2021). Neonatal hyperthyroidism: clinical features, diagnosis, and management. Pediatr Neonatol. 62(1): 17-25.
Yeh & Chen (2018). Long-term neurodevelopmental outcomes in infants with congenital hyperthyroidism. J Clin Endocrinol Metab. 103(11): 4107-4114.
Kusters et al. (2019). Autoimmune neonatal thyrotoxicosis: a review. Horm Res Paediatr. 91(4): 231-240.
Miller et al. (2020). Maternal thyroid disease and fetal/neonatal outcomes. Curr Opin Endocrinol Diabetes Obes. 27(5): 363-368.
Rogers et al. (2018). Impact of early treatment of neonatal hyperthyroidism on neurodevelopmental outcomes. J Pediatr. 202: 102-108.
Liu & Wang (2019). Developmental sequelae of neonatal hyperthyroidism. Endocrinol Metab Clin North Am. 48(4): 109-122.
Haddad & Nair (2022). Current management of neonatal hyperthyroidism. Pediatr Drugs. 24(2): 123-132.
Kordonouri et al. (2020). Spontaneous remission of neonatal hyperthyroidism: a systematic review. Horm Res Paediatr. 93(1): 22-30.
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2025 Hiuneicy Gonzalez Villaviencio, Mónica Julissa Angulo Barranca, Carmen Ávila García Ávila García
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors will retain the copyright and grant the right to publish their work in the journal while allowing third parties to share it under the Creative Commons Attribution license.
Articles are published under a Creative Commons license that allows sharing and adaptation with appropriate credit. CC BY 4.0 license. Available in English at https://creativecommons.org/licenses/by/4.0/
Authors may use other information disclosure formats as long as the initial publication in the journal is cited. The dissemination of the work through the Internet is recommended to increase citations and promote academic exchanges.
The published content does not necessarily reflect the specific point of view of the journal, and the authors assume full responsibility for the content of their article.
