Clinical response to hormone replacement therapy in patients with Growth Hormone deficiency
DOI:
https://doi.org/10.61651/rped.2011v64n2p25-34Keywords:
Body Height, Dwarfism, PituitaryAbstract
The treatment of the patients with short stature caused by growth hormone deficiency (GHD) is realized on the basis of the hormonal replacement which has a positive impact on the clinical, psychological and social setting.
Objective: To describe the clinical response, to the therapy of hormonal replacement, of the patients with isolated growth hormone deficiency, attended in the Peruvian Endocrinology Unit at Instituto Nacional de Salud del Niño.
Methods: This is a descriptive, retrospective and longitudinal study. We reviewed the clinical response to the therapy of hormonal replacement of 10 patients with growth hormone deficiency. Results: The age of diagnosis was 4.54 ± 2.4 years; the age at the beginning of the hormone replacement was 5.9 ± 2.8 years. The growth velocity was 4.5cm/year pretreatment and increased since the 6th month of treatment, reaching 11.6 cm /year at the end of the first year of hormone replacement. The score of the standard deviation (SDS) of the pretreatment height was -4.19 ± 0.74 and -2.87±0.73 at the end of the first year of treatment. Height gain according to the Bayley-Pinneau’s method was 8.2 cm after one year and 10 cm after 2 years of treatment. We did not find any alterations in the glucose levels and lipids profile.
Conclusions: The treatment with the Growth hormone was effective in increasing the height in the patients with isolated of hormone of growth.
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