Type I diabetes mellitus in Chilean children under 5 years-old: Onset characteristics in contrast with other age groups

Authors

  • Francisca Eyzaguirre Croxatto
  • José Miguel Peláez D.
  • Carolina Sepúlveda R.
  • Ximena Gaete V.
  • Ethel Codner D.
  • Nancy Unanue M.
  • Alejandra Ávila A.
  • Francisca Ugarte P.
  • Ricardo Silva A.
  • Hernán García B.

DOI:

https://doi.org/10.61651/rped.2008v61n1p22-27

Keywords:

Diabetes Mellitus, Type 1, Child

Abstract

Background: During the last years, an increase in the incidence of DM1 in infants has been observed. Objective: To study the number of children younger than 5 years old diagnosed with DM1 and compare clinical and laboratory features with older children at DM1 onset. Method: Study of the clinical and laboratory characteristics in subjects diagnosed with DM1 from 1998 to 2003 in Santiago. Patients were classified according to age in 3 groups: 0-4 (GI), 5-9 (GII) and 10-14 years old (GIII). Results: 19,7% cases were younger than 5 years old (GI n = 27), GII (43,8% n = 60) and GIII (36,5% n = 50). A shorter duration of symptoms was observed in GI (18,4 ± 23,7 vs 26,4 ± 27,4) (p < 0,0001) and HbA1c levels were lower in GII (10,1 ± 1,7 vs 11,8 ± 3,4%) (p < 0,0001) and in GIII (12,4 ± 2,6%) (p = 0,028). Glucose levels were similar among groups (p>0,05) and metabolic acidosis was more severe in GI (pH 7,14 ± 0,1 vs 7,19 ± 0,2 in GII and 7,26 ± 0,1 in GIII) (p < 0,0001). A concomitant infectious disease was observed in GI (33%), GII (20%) and GIII (28%) (p > 0,05). Conclusions: An important percentage of DM1 in children presents in subjects younger than 5 years old. This group showed acute and severe clinical presentation with longer duration of symptoms, severe acidosis and lower HbA1c levels. It is necessary to evaluate carefully in order to suspect the diagnosis in this group. 

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Published

2008-12-31

How to Cite

1.
Eyzaguirre Croxatto F, Peláez D. JM, Sepúlveda R. C, Gaete V. X, Codner D. E, Unanue M. N, et al. Type I diabetes mellitus in Chilean children under 5 years-old: Onset characteristics in contrast with other age groups. Rev Peru Pediatr [Internet]. 2008 Dec. 31 [cited 2025 Feb. 21];61(1):22-7. Available from: https://pediatria.pe/index.php/pedperu/article/view/222

Issue

Vol. 61 Num. 1 (2008)

Section

ORIGINAL ARTICLE

Categories

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